INHALED NITRIC OXIDE (NO) INHIBITS PLATELET AGGREGATION IN CRITICALLY ILL NEONATES. † 843
نویسندگان
چکیده
منابع مشابه
Annotation Inhaled nitric oxide in neonates
Scientific foundation Nitric oxide (NO) is a major regulator of vascular smooth muscle tone. Generated enzymatically by one of several NO synthases from L-arginine, NO activates guanylyl cyclase by binding to its haem component, leading to the production of cyclic GMP. 4 This then relaxes vascular and bronchial smooth muscle by a mechanism which probably involves inhibition of an activation ind...
متن کاملAnnotation Inhaled nitric oxide in neonates
Scientific foundation Nitric oxide (NO) is a major regulator of vascular smooth muscle tone. Generated enzymatically by one of several NO synthases from L-arginine, NO activates guanylyl cyclase by binding to its haem component, leading to the production of cyclic GMP. 4 This then relaxes vascular and bronchial smooth muscle by a mechanism which probably involves inhibition of an activation ind...
متن کاملInhaled epoprostenol vs inhaled nitric oxide for refractory hypoxemia in critically ill patients.
PURPOSE The purpose of this is to compare efficacy, safety, and cost outcomes in patients who have received either inhaled epoprostenol (iEPO) or inhaled nitric oxide (iNO) for hypoxic respiratory failure. MATERIALS AND METHODS This is a retrospective, single-center analysis of adult, mechanically ventilated patients receiving iNO or iEPO for improvement in oxygenation. RESULTS We evaluated...
متن کاملNitric oxide production in critically ill patients.
OBJECTIVE To measure serum nitrite and nitrate levels in critically ill children as indicators of endogenous nitric oxide (NO) production. HYPOTHESIS Endogenous NO production is increased in children with conditions characterised by immune stimulation. DESIGN Prospective descriptive study in a multidisciplinary paediatric intensive care unit. PATIENTS 137 consecutive critically ill childr...
متن کاملInhaled nitric oxide inhibits human platelet aggregation, P-selectin expression, and fibrinogen binding in vitro and in vivo.
BACKGROUND Recent data suggest that inhaled NO can inhibit platelet aggregation. This study investigates whether inhaled NO affects the expression level and avidity of platelet membrane receptors that mediate platelet adhesion and aggregation. METHODS AND RESULTS In 30 healthy volunteers, platelet-rich plasma was incubated with an air/5% CO2 mixture containing 0, 100, 450, and 884 ppm inhaled...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1997
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199704001-00863